Fill a Gab(1) in Cardiac Hypertrophy Signaling
نویسندگان
چکیده
منابع مشابه
cGKI signaling in cardiac hypertrophy
The atrial natriuretic peptide (ANP) has been shown to modulate hypertrophy of the heart via the cardiac NP receptor guanylyl cyclase-A (GC-A) [1]. Also, analysis of transgenic mice with a cardiomyocyte (cM) specific overexpression of GC-A and the chronic inhibition of the cGMP-degrading phosphodiesterase-5 by sildenafil indicated that the second messenger cGMP can blunt hypertrophic signals fr...
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Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy. We have discovered that the A-Kinase Anchoring Protein (AKAP)-Lbc is upregulated in hypertrophic cardiomyocytes. It coordinates activation and movement of signaling proteins that initiate MEF2-mediated tran...
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Cardiac hypertrophy involves increased mass (growth) of the heart and a cardinal feature of this condition is increased rates of protein synthesis. Several signaling pathways have been implicated in cardiac hypertrophy including the phosphatidylinositol 3-kinase (PI3K) and Ras/Raf/MEK/Erk pathways. PI3K lies upstream of the mammalian target of rapamycin (mTOR), an important positive regulator o...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000087333.88497.ae